Oxandrol (Anavar) by GenShi Labs is a synthetic anabolic steroid which contain 10mg per tab of the hormone Oxandrolone and it is merchandised in a pack with 30 tabs. For the first time it was Produced by Serle Laboratories, now called Pfizer Inc., and was introduced in United States in 1964. At the beginning this anabolic steroid was used for different kind of diseases, which provoked a quick weight loss, to improve the muscle grow process. Later it was noticed that Anavar helps really great in treating osteoporosis. In 1989 Searle Laboratories Inc. stopped to produce this drug due the abusive use by a lot of bodybuilders. After that Anavar was picked up by Bio-Technology General Corporation, now called Savient Pharmaceuticals, Inc. This company made a lot of successful clinical trials in 1995 and named Anavar Oxandrin.
It was approved for orphan drug status by the Food and Drug Administration (FDA) in treating alcoholic hepatitis, Turner’s syndrome, and weight loss caused by HIV. In addition, the drug has shown positive results in treating anemia and hereditary angioedema. In a randomized, double-blind study, patients with 40% total body surface area burns were selected to receive standard burn care plus Oxandrolone, or without Oxandrolone. Those treated with Oxandrolone showed improve body composition, preserved muscle mass and reduced hospital stay time. Before the Controlled Substances Act was passed to restrict the production, sale, and usage of anabolic steroids, Oxandrolone’s characteristics lent itself well towards use by female athletes. Its specificity targeting the androgen receptor meant that, unlike many other steroids, it had not been reported to cause stunted growth in younger users (because it doesn’t convert to estrogen, that’s the reason women typically don’t grow as tall as men they have more estrogen) and at typical dosage rarely caused noticeable masculinising effects outside of stimulating muscle growth. It is not easily metabolised into DHT or estrogen. As such, a typical dose of 20-30 mg provided elevated androgen levels for up to eight hours. To increase effectiveness, bodybuilders typically “stacked” the drug with others such as Testosterone, further enhancing body mass gain.
Unlike other anabolic steroids Oxandrolone has two major advantages: First, it does not convert to estrogen which causes gynecomastia . Second, it does not significantly influence the body’s normal testosterone production (HPTA axis) at low dosages (10mgs). When dosages are high (this goes for any anabolic steroid) then your body feels that it has enough testosterone and it reduces the production of LH (luteinizing hormone) which no longer stimulates Leyding cells in testicles to produce testosterone therefore causing testicular atrophy (shrinking). Post Cycle Therapy (PCT) is of course needed for high dosages (4050 mg) of this synthetic derivative of testosterone because as the dosage increases the influence on HPTA is bigger. Lack of PCT will of course lead to protein catabolism until body’s normal testosterone secretion is back to normal. Bodybuilders consider a normal dose for a novice 2030 mg per day, when in fact 10 mg is more than enough for someone who has never used it[unreliable source?]. Higher dosages not only lead to AR (Androgen Receptor) down regulation and HPTA suppression but also damage the liver being a 17-alkylated steroid. It is specifically made 17-alkylated because if it weren’t the liver would consider it a toxin and destroy it.Since Searle stopped production, biggest sellers are La Pharma Italy and British Dragon Thailand.
Many studies have shown links between prolonged use of the Anavar and problems of liver toxicity similar to those found with other 17aa steroids. Even in small dosages, many users reported gastro-intestinal problems such as bloating, nausea, skin rash and itching (hives), black, tarry stools or light-colored stools, depression, unusual bleeding, unusual swelling, yellowing of the eyes or skin, and diarrhea.In rare cases, serious and even fatal cases of liver problems have developed during treatment with oxandrolone. Oxandrolone may increase the amount of low density lipoprotein (LDL; ‘bad cholesterol’) and decrease the amount of high density lipoprotein (HDL; ‘good cholesterol’) in the blood. This may increase the risk of developing heart disease. Oxandrolone may damage the liver or increase LDL without causing symptoms. It is important to have regular laboratory tests to be sure that the liver is working properly and that LDL has not increased. Oxandrolone may also decrease fertility in men.